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Role of Polypeptide Inflammatory Biomarkers in the Diagnosis and Monitoring of COVID-19

Aparajita Sen1, Arti Nigam2, Meenakshi Vachher3

  • 1Department of Genetics, University of Delhi South Campus, New Delhi, 110021 India.

International Journal of Peptide Research and Therapeutics
|January 31, 2022
PubMed

Insights

Early detection of COVID-19 is crucial. This review highlights key inflammatory biomarkers like C-reactive protein and Interleukin-6 for timely diagnosis and patient management.

Area of Science:

  • Biochemistry
  • Immunology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic caused global devastation with a wide range of symptoms.
  • Accurate diagnosis and severity assessment are vital for effective COVID-19 treatment.
  • Early detection is needed to manage viral load and patient outcomes.

Purpose of the Study:

  • To review critical polypeptide inflammatory biomarkers for COVID-19 detection and management.
  • To explore the role of biomarkers in viral pathogenesis and disease progression.
  • To emphasize the need for further research on these biomarkers.

Main Methods:

  • Literature review of inflammatory biomarkers.
  • Analysis of biomarker roles in COVID-19 pathogenesis.
  • Correlation of biomarkers with disease progression.

Main Results:

  • Identified key biomarkers: C-reactive protein, Procalcitonin, Ferritin, Lactate Dehydrogenase, Serum amyloid A, Interleukin-6, Tumor necrosis factor-alpha, and LIGHT.
  • Highlighted their utility in COVID-19 detection and severity assessment.
  • Emphasized the link between biomarkers, viral pathogenesis, and disease progression.

Conclusions:

  • Inflammatory biomarkers are essential for early COVID-19 diagnosis and patient stratification.
  • Integrative monitoring of biomarkers aids in managing COVID-19 progression.
  • Further research is warranted to fully understand and utilize these biomarkers.

Keywords:
C- reactive proteinCOVID-19FerritinInflammationInterleukin-6LIGHTLactate dehydrogenaseProcalcitoninProtein biomarkersSerum amyloid ATNF-α

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