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Crocetin: A Systematic Review.

Zi-Liang Guo^1,2, Mao-Xing Li^1,2,3, Xiao-Lin Li¹

¹Department of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, China.

Frontiers in Pharmacology

|January 31, 2022

Summary

This summary is machine-generated.

Crocetin, a bioactive metabolite from saffron and cape jasmine, shows diverse therapeutic benefits including heart, liver, and brain protection. Research is advancing its potential despite bioavailability challenges.

Keywords:

crocetin crocetin derivatives distribution formulation pharmacokinetics pharmacological activity toxicity

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Area of Science:

Pharmacology
Natural Products Chemistry
Medicinal Chemistry

Background:

Crocetin is a bioactive metabolite derived from crocin, found in saffron and cape jasmine.
It is recognized for its presence in various medicinal plants.
Biological production involves the hydrolysis of crocin.

Purpose of the Study:

To comprehensively review the distribution, synthesis, and derivatization of crocetin.
To summarize the pharmacological activities and pharmacokinetic properties of crocetin.
To discuss drug safety, formulations, and preparation technologies for crocetin.

Main Methods:

Literature review on crocetin's natural occurrence and synthesis.
Compilation of data on pharmacological investigations.
Analysis of studies on derivatization and formulation technologies.

Main Results:

Crocetin exhibits a wide range of pharmacological effects: cardioprotective, hepatoprotective, neuroprotective, antidepressant, antiviral, anticancer, anti-atherosclerotic, antidiabetic, and memory-enhancing.
Poor bioavailability is a key limitation for therapeutic use.
Advancements in derivatization and formulation enhance its application potential.

Conclusions:

Crocetin is a promising natural compound with extensive therapeutic potential.
Further research and development in formulation and derivatization are crucial for its clinical application.
This review aims to facilitate future research and development of crocetin.