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Updated: Oct 5, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Prognostic Signatures and Therapeutic Value Based on the Notch Pathway in Renal Clear Cell Carcinoma

Ziyao Li1,2, Shiyong Xin3,4, Shuanbao Yu1

  • 1Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Oxidative Medicine and Cellular Longevity
|January 31, 2022
PubMed

Insights

This study explores the Notch pathway

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Notch signaling pathway is crucial for cell development and is implicated in various cancers.
  • Abnormal Notch gene expression is linked to cancer development, but specific treatments for renal cell carcinoma (RCC) targeting this pathway are lacking.

Purpose of the Study:

  • To investigate the role and therapeutic potential of the Notch pathway in kidney renal clear cell carcinoma (KIRC).
  • To identify potential therapeutic targets and predict patient prognosis based on Notch pathway gene expression.

Main Methods:

  • Analysis of Notch pathway genes across tumor types, focusing on KIRC.
  • Clustering KIRC patient samples based on Notch gene mRNA expression.
  • Prediction of IC50 values for targeted therapies and correlation with the Notch pathway.
  • Utilized LASSO regression for survival prediction modeling in KIRC patients.

Main Results:

  • KIRC patient samples were classified into three distinct clusters based on Notch pathway gene expression.
  • Identified correlations between Notch pathway activity and the efficacy of targeted therapies.
  • Developed a predictive model for KIRC patient survival using Notch pathway gene expression.

Conclusions:

  • Notch pathway-targeted therapies may be optimized using a 'Notch score' for KIRC.
  • Notch pathway gene expression can predict KIRC patient prognosis.
  • Provides a foundation for developing novel therapeutic strategies for KIRC targeting the Notch pathway.

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