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Diffuse large B-cell lymphoma with uncommon cardiac invasion
Yunis Daralammouri1,2, Hamza Hamayel3, Yahya Ismail1,2
1Department of Cardiology, An-Najah National University Hospital, Nablus, Palestine.
SAGE Open Medical Case Reports
|January 31, 2022
Summary
Diffuse large B-cell lymphoma, a common non-Hodgkin lymphoma, can uncommonly present as an intracardiac mass. Early diagnosis and R-CHOP chemotherapy led to complete resolution in a young female patient.
Area of Science:
- Cardiology
- Oncology
- Hematology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma.
- Cardiac involvement by DLBCL is typically a late manifestation in advanced disease.
Observation:
- A 26-year-old female presented with symptoms suggestive of cardiac obstruction.
- Echocardiography and CT revealed a large right atrial mass obstructing the tricuspid valve.
- Histopathology confirmed the mass as DLBCL.
Findings:
- The patient received six cycles of R-CHOP chemotherapy.
- Complete resolution of the intracardiac DLBCL mass was achieved.
Implications:
- DLBCL can present atypically with primary cardiac involvement.
- Early detection and prompt treatment are critical for favorable outcomes in cardiac DLBCL.
- A high index of suspicion and appropriate imaging are essential for diagnosing rare presentations of DLBCL.
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