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Updated: Oct 5, 2025
Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
Tissue Doppler, speckling tracking and four-dimensional echocardiographic assessment of right ventricular function in
Mohammed Al-Biltagi1, Osama Elrazaky1, Wegdan Mawlana1
1Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 31512, Algharbia, Egypt.
Insights
Right ventricular (RV) function declines in children with idiopathic dilated cardiomyopathy (DCM). Advanced echocardiography (2-D-STE, TDI, 4-DE) detects this early RV dysfunction, aiding diagnosis and management.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Imaging
- Cardiac Physiology
Background:
- Right ventricular (RV) function is often underestimated in evaluations of dilated cardiomyopathy (DCM).
- Early detection of RV dysfunction is crucial for managing pediatric DCM.
Purpose of the Study:
- To assess RV function in children with idiopathic DCM.
- Utilize advanced echocardiographic techniques including four-dimensional echocardiography (4-DE), Tissue Doppler Imaging (TDI), and two-dimensional speckle-tracking echocardiography (2-D-STE).
Main Methods:
- Prospective study of 50 children with idiopathic DCM and 50 healthy controls.
- Evaluation of RV ejection fraction (EF) using 4-DE.
- Assessment of RV global longitudinal strain (GLS) and other systolic/diastolic parameters via TDI and 2-D-STE.
Main Results:
- Children with DCM showed significantly lower left and right ventricular ejection fractions and GLS.
- Impaired RV systolic and diastolic parameters (e.g., S wave, MPI, TAPSE) were observed in DCM patients.
- RV GLS correlated with disease duration and specific RV functional parameters.
Conclusions:
- Children with DCM exhibit impaired RV global longitudinal strain and other echocardiographic parameters.
- 2-D-STE and TDI are valuable tools for detecting early declines in RV function in pediatric DCM.
Background:
Right ventricular (RV) function is frequently overlooked during dilated cardiomyopathy (DCM) evaluation.
Aim:
To evaluate RV function in children with idiopathic DCM using relatively recent echocardiographic modalities.
Methods:
We prospectively studied the cardiac function in 50 children with idiopathic DCM and 50 healthy children as a control group, using four-dimensional echocardiography (4-DE), Tissue Doppler Imaging (TDI), and two-dimensional-speckles tracking echocardiography (2-D-STE). RV EF was measured by 4-DE.
Results:
The auto left (LV) ejection fractions (EF) measured by 2-D-STE were significantly lower in the patients' group than in the control. The sphericity index was also significantly lower in children with DCM than in the control. RV EF measured by 4-DE was significantly lower in the patient's group than the control. RV S wave, e´/a' ratio, myocardial performance index (MPI), and tricuspid annular plane systolic excursion (TAPSE) were significantly impaired in children with DCM than in control. Both LV and RV global longitudinal strains (GLS) were significantly reduced in children with DCM than in control. RVGLS was significantly associated with the duration since diagnosis, tricuspid annulus S wave, RV MPI, and TAPSE, but not with the age of the patients, RV EF, or e´/a' ratio.
Conclusion:
There was impairment of the RV LGS and other systolic and diastolic parameters in children with DCM. STE and TDI can help to detect the early decline of RV function.
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