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Clinical Correlation Between Overactive Bladder and Allergy in Children.
Lu Yin1, Zhou Zhang1, Yue Zheng1
1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Frontiers in Pediatrics
|January 31, 2022
Summary
Overactive bladder (OAB) in children is linked to allergies. The antihistamine desloratadine effectively improved OAB symptoms in children with allergies, particularly those with allergic rhinitis or cough.
Area of Science:
- Pediatric Urology
- Allergology
- Clinical Research
Background:
- Overactive bladder (OAB) is defined by the International Children's Continence Society as urinary urgency, often with frequency and nocturia.
- This study investigates the potential association between OAB and allergic conditions in pediatric patients.
Purpose of the Study:
- To explore the correlation between overactive bladder (OAB) and allergies in children.
- To evaluate the efficacy of desloratadine in treating OAB in pediatric patients with allergies.
Main Methods:
- Retrospective analysis of clinical data from 918 pediatric patients diagnosed with OAB.
- Logistic regression analysis to identify OAB risk factors.
- Assessment of desloratadine's therapeutic effect on OAB in allergic children.
Main Results:
- Higher incidence of allergic cough or rhinitis observed in the mild OAB group compared to the moderate-severe OAB group.
- Urodynamic findings indicated a greater proportion of sensitive bladders in patients with overactive detrusors.
- Desloratadine treatment achieved a 90.14% effective rate in allergic OAB patients, significantly higher than in non-desloratadine users. Elevated blood IgE levels were identified as a risk factor for ineffective desloratadine treatment.
Conclusions:
- A significant correlation exists between overactive bladder (OAB) and allergies in the pediatric population.
- Desloratadine demonstrates significant efficacy in improving OAB symptoms in children with comorbid allergic conditions.
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