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Adipose Stem Cells in Regenerative Medicine: Looking Forward
Sara Al-Ghadban1, Maria Artiles1, Bruce A Bunnell1
1Department of Microbiology Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, United States.
Frontiers in Bioengineering and Biotechnology
|January 31, 2022
Summary
Adipose stem cells (ASCs) show promise in regenerative medicine for various diseases and injuries. Their therapeutic potential is driven by secreted factors and interactions, with future applications including complex tissue engineering.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Tissue Engineering
Background:
- Stem cell therapies have advanced to clinical applications over the past decade.
- Adult stem cells from adipose tissue (ASCs) offer therapeutic potential for diverse conditions.
- ASCs' regenerative capacity relies on their secretome and cell-matrix interactions.
Purpose of the Study:
- To review current and future applications of adipose stem cells (ASCs) in regenerative medicine.
- To highlight the mechanisms underlying ASCs' therapeutic effects.
- To discuss the progression towards complex tissue and organ regeneration using ASCs.
Main Methods:
- Review of existing literature on adipose stem cells (ASCs) in regenerative medicine.
- Analysis of ASC secretome and cell-matrix interaction roles.
- Exploration of advancements in 3D organoid and tissue engineering with ASCs.
Main Results:
- ASCs show promise in treating autoimmune, neurodegenerative, vascular, and metabolic diseases.
- Applications include bone and cartilage regeneration and wound healing.
- Emerging strategies focus on creating complex 3D structures for tissue replacement.
Conclusions:
- Adipose stem cells (ASCs) are versatile tools in regenerative medicine.
- The secretome and cell-matrix interactions are key to ASC therapeutic functions.
- Future directions involve advanced tissue engineering for organ repair and replacement.
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