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Therapeutic Mesenchymal Stem/Stromal Cells: Value, Challenges and Optimization.
Mehdi Najar1,2, Rahma Melki3, Ferial Khalife4
1Laboratory of Clinical Cell Therapy, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Frontiers in Cell and Developmental Biology
|January 31, 2022
Summary
Mesenchymal stem/stromal cells (MSCs) are promising for tissue repair and treating diseases. Their therapeutic potential depends on understanding their properties, optimizing culture, and delivery for better clinical outcomes.
Area of Science:
- Cellular and regenerative medicine
- Stem cell biology
Background:
- Mesenchymal stem/stromal cells (MSCs) are key to tissue homeostasis and repair.
- Their therapeutic applications are explored for immunological, inflammatory, degenerative diseases, and cancer.
Purpose of the Study:
- To review recent findings on MSC properties and therapeutic potential.
- To discuss challenges and optimization strategies for clinical use of MSCs.
Main Methods:
- Literature review summarizing current research on MSCs.
- Analysis of MSC origin, function, and therapeutic mechanisms.
Main Results:
- MSCs exhibit fibroblast-like morphology and are sensitive to environmental factors.
- Therapeutic effects are mediated by secreted factors, including extracellular vesicles.
- Consensus on MSC nomenclature and identification of subpopulations requires further study.
Conclusions:
- Understanding MSCs' stemness, origin, and function is crucial for clinical application.
- Optimizing culture conditions, delivery methods, and understanding MSC immunobiology are key to improving therapeutic outcomes.
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