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Updated: Oct 5, 2025

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
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Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima

Published on: August 12, 2018

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FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases

Guoyong Li1,2,3, Junli Li1, Ruochen Shao1,2,3

  • 1Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Cell and Developmental Biology
|January 31, 2022
PubMed

Insights

Mitochondrial autophagy receptor FUNDC1 plays a key role in cardiovascular diseases (CVDs). Its regulation of mitophagy impacts heart function, potentially offering a new therapeutic target for CVDs.

Area of Science:

  • Cell Biology
  • Cardiovascular Research
  • Mitochondrial Dynamics

Background:

  • Mitochondrial autophagy (mitophagy) is crucial for cellular health and cardiovascular function.
  • Homeostatic mitophagy's protective role in cardiovascular diseases (CVDs) is gaining attention.
  • FUN14 domain containing 1 (FUNDC1) is an identified mitophagy receptor implicated in CVDs.

Purpose of the Study:

  • To review the multifaceted roles of FUNDC1 in various cardiovascular diseases.
  • To elucidate FUNDC1's interactions with cellular organelles and its involvement in cellular processes.
  • To explore FUNDC1's potential as a therapeutic target for CVDs.

Main Methods:

  • Literature review summarizing existing research on FUNDC1 in CVDs.
  • Analysis of FUNDC1's role in mitophagy regulation.
  • Investigation of FUNDC1's involvement in mitochondria-associated membranes (MAMs) and calcium homeostasis.

Main Results:

  • FUNDC1 expression and phosphorylation influence outcomes in hypoxia, ischemia/reperfusion injury, cardiac hypertrophy, and metabolic damage.
  • FUNDC1 regulates mitochondrial dynamics and calcium homeostasis via MAMs.
  • FUNDC1 is involved in inflammatory conditions like septic cardiomyopathy.

Conclusions:

  • FUNDC1's diverse roles in cardiovascular pathophysiology are highlighted.
  • FUNDC1's interactions with organelles and signaling pathways are critical for heart function.
  • FUNDC1 presents a promising therapeutic avenue for cardiovascular disease prevention and management.
Keywords:
FUNDC1LC3MAMcardiovascular diseasesmitophagy

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