Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...

Positive Regulator Molecules

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnostic and treatment preferences for cracked posterior teeth.

Australian dental journal·2023

Same author

New concept: "TARN friendly trauma reporting" (what radiologists say really does matter).

Clinical radiology·2021

Same author

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2020

Same author

The effect of exercise on local and systemic adverse reactions after vaccinations - Outcomes of two randomized controlled trials.

Vaccine·2018

Same author

Sodium salicylate reduces the level of GABAB receptors in the rat's inferior colliculus.

Neuroscience·2015

Same author

Prolonged altered mental status and bradycardia following pediatric donepezil ingestion.

Clinical toxicology (Philadelphia, Pa.)·2014

Search research articles

Related Experiment Video

Updated: Oct 5, 2025

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation.

E Fidalgo da Silva¹, J Fong¹, A Roye-Azar¹

¹Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.

Frontiers in Cell and Developmental Biology

|January 31, 2022

Summary

The Tuberous Sclerosis Complex integrates environmental signals to control cell cycle progression. This review highlights its critical role in linking cellular sensing to cell cycle machinery.

Keywords:

TSC cell cycle cell growth mTOR tuberin tuberous sclerosis complex

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Analysis of Cell Cycle Position in Mammalian Cells

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Related Experiment Videos

Last Updated: Oct 5, 2025

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Analysis of Cell Cycle Position in Mammalian Cells

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Cellular sensing of environmental signals (nutrients, stress) is vital for physiological responses in prokaryotes and eukaryotes.
Biochemical pathways for signal detection are well-known, but signal integration controlling cell cycle progression is an active research area.
The Tuberous Sclerosis Complex (TSC), comprising Tuberin, Hamartin, and TBC1D7, is a large protein complex known to regulate diverse cellular events.

Purpose of the Study:

To review the literature on the Tuberous Sclerosis Complex's role in integrating environmental signals with cell cycle machinery.
To emphasize the TSC's function beyond protein synthesis regulation, focusing on cell cycle control.
To consolidate current understanding of how TSC integrates environmental cues to modulate cell cycle progression.

Main Methods:

Literature review of studies on the Tuberous Sclerosis Complex.
Analysis of molecular pathways involved in TSC signaling.
Examination of post-translational modifications of Tuberin and their impact on cellular pathways.
Focus on the integration of environmental signals with cell cycle regulation.

Main Results:

The Tuberous Sclerosis Complex integrates diverse environmental signals, including nutrient availability and stress.
TSC controls numerous cell biology events: protein synthesis, cell cycle, protein transport, cell adhesion, autophagy, and cell growth.
Post-translational modifications of Tuberin convey environmental messages to these pathways, with a historical focus on protein synthesis regulation.

Conclusions:

The Tuberous Sclerosis Complex is a critical integrator of environmental signals and the core cell cycle machinery.
Environmental cues are effectively relayed through TSC to modulate cell cycle progression.
Further research is warranted to fully elucidate the mechanisms by which TSC governs cell cycle control in response to environmental stimuli.