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Published on: September 25, 2019
Hepatitis B Virus Reactivation Associated With Therapeutic Interventions
Young Chang1, Soung Won Jeong1, Jae Young Jang1
1Department of Internal Medicine, Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, South Korea.
Hepatitis B virus (HBV) reactivation poses significant risks during cancer therapy and immunosuppression. Understanding HBV reactivation mechanisms is crucial for managing patients with current or past HBV infection.
Area of Science:
- Hepatology
- Immunology
- Oncology
Background:
- Hepatitis B virus (HBV) reactivation is a significant cause of morbidity and mortality in patients undergoing various therapeutic interventions.
- No curative treatment for HBV infection exists, leaving a large population susceptible to reactivation.
- Populations at risk include those with current or resolved HBV infection, especially when exposed to immunosuppressive or immunomodulatory therapies.
Purpose of the Study:
- To raise awareness of Hepatitis B virus (HBV) reactivation.
- To elucidate the mechanisms underlying HBV reactivation.
- To identify risks associated with HBV reactivation in diverse clinical settings.
Main Methods:
- This review synthesizes existing literature on HBV reactivation.
- It focuses on therapeutic interventions, including anti-cancer chemotherapy and immunosuppressive/immunomodulatory agents.
- Mechanisms of reactivation and clinical risk factors are examined.
Main Results:
- Various therapeutic interventions, particularly anti-cancer chemotherapy and immunosuppressive/immunomodulatory therapies, can trigger HBV reactivation.
- Patients with current or resolved HBV infection are at risk.
- Understanding the mechanisms is key to mitigating risks.
Conclusions:
- Awareness of HBV reactivation risks is critical for clinicians managing at-risk populations.
- Further understanding of reactivation mechanisms can inform preventative strategies.
- Proactive management is essential to reduce morbidity and mortality associated with HBV reactivation.
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