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Updated: Oct 5, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

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Decreased CDKL2 Expression in Clear Cell Renal Cell Carcinoma Predicts Worse Overall Survival

Zhan Chen1, Yan Lv1, Lu He1

  • 1Department of Urology, CR & WISCO General Hospital, Wuhan University of Science and Technology, Wuhan, China.

Frontiers in Molecular Biosciences
|January 31, 2022
PubMed

Insights

Decreased expression of cyclin-dependent kinase-like 2 (CDKL2) is linked to poor prognosis in clear cell renal cell carcinoma (ccRCC). This study identifies CDKL2 as a potential biomarker associated with immune cell infiltration in ccRCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • Clear cell renal cell carcinoma (ccRCC) is a prevalent and lethal kidney cancer.
  • The prognostic value and mechanism of cyclin-dependent kinase-like 2 (CDKL2) in ccRCC remain unelucidated, despite its known association with other cancers.

Purpose of the Study:

  • To investigate the prognostic significance of CDKL2 expression in ccRCC.
  • To explore the potential mechanisms underlying CDKL2's role, particularly its association with immune infiltration in ccRCC.

Main Methods:

  • Gene expression analysis utilizing TCGA, GEO, and ICGC databases.
  • Clinicopathologic, survival, co-expression network, enrichment, methylation, and immune infiltration analyses were performed on TCGA-ccRCC data.
  • Protein expression levels were assessed using The Human Protein Atlas.

Main Results:

  • CDKL2 expression was found to be decreased in ccRCC tissues across multiple databases.
  • Downregulation of CDKL2 correlated with adverse clinicopathologic features and served as an independent prognostic factor for poor survival.
  • CDKL2 expression was significantly associated with various immune cell infiltrates, including T cells, monocytes, and macrophages.

Conclusions:

  • This study is the first to report on CDKL2 expression in ccRCC, indicating its downregulation is linked to poor prognosis.
  • CDKL2 is proposed as a novel prognostic biomarker in ccRCC, with its expression closely correlating with immune infiltrates.
Keywords:
Cdkl2biomarkerclear cell renal cell carcinomaimmune infiltratesoverall survival

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