Related Experiment Video
Updated: Oct 5, 2025

Gastrointestinal Motility Monitor GIMM
Published on: December 1, 2010
Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
Crista Ulteig1, Kristin Ciezki1,2, Megan Jacobson1
1Advocate Aurora Health Department of Gastroenterology and Hepatology, Milwaukee, WI.
Abstract:
Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well documented. We report a case series of 3 patients with coexisting esophageal dysmotility and constipation on chronic opioids that improved both symptoms after starting naloxegol. Based on these observational studies, we propose that formal studies be conducted to assess the effect of naloxegol on opioid-induced esophageal dysmotility.
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