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Blepharospasm and autoimmune diseases.

J Jankovic1, B M Patten

  • 1Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1987
PubMed
Summary
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Blepharospasm may be linked to autoimmune disorders like systemic lupus erythematosus and myasthenia gravis. Treatment of the underlying autoimmune condition with immunosuppressants improved blepharospasm in two patients.

Area of Science:

  • Neurology
  • Immunology
  • Ophthalmology

Background:

  • Blepharospasm is an involuntary eyelid twitching condition.
  • Autoimmune diseases involve the immune system attacking the body's own tissues.

Observation:

  • Two patients with autoimmune diseases (systemic lupus erythematosus and myasthenia gravis) presented with blepharospasm.
  • Blepharospasm symptoms coincided with flare-ups of their respective autoimmune conditions.

Findings:

  • Blepharospasm improved in both patients following immunosuppressive therapy for their autoimmune diseases.
  • This suggests a potential association between blepharospasm and autoimmune disorders.

Implications:

  • Blepharospasm may be a manifestation of underlying autoimmune processes.

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  • Further research is warranted to explore the link between blepharospasm and autoimmunity.
  • Considering autoimmune etiologies may be beneficial in managing refractory blepharospasm.