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Updated: Oct 5, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Evidence-based strategies for better antibiotic prescribing
Parker Magin1, Andrew R Davey2, Joshua Davis3
1PhD, FRACGP, Conjoint Professor, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW; Director, GP Synergy NSW @ ACT Research and Evaluation Unit, Mayfield, NSW.
Background:
Antibiotic resistance is a key global health threat, and antibiotic overuse is a significant contributing factor. Antibiotic stewardship is a vital issue for general practice.
Objective:
The aim of this article is to discuss evidence-based strategies for general practitioners (GPs) and general practices to contribute to antibiotic stewardship and, thus, reduce the overall burden of antibiotic prescribing in the community.
Discussion:
For individual GPs, and for practices, there is good evidence for the effectiveness of several strategies. As well as having a firm grasp of the clinical evidence in the area, important strategies for GPs include: eliciting and exploring patient understanding and expectations, and incorporating these in communication and management; offering delayed prescribing; using appropriate non-antibiotic symptomatic management; and, when prescribing antibiotics, doing so only for genuine clinical indications, with the appropriate antibiotic, at the appropriate dose, for the shortest appropriate duration. Practices can adopt a practice culture and practice-wide prescribing policies that promote antibiotic stewardship.
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