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Cellular senescence in the cholangiopathies
Pamela S Bogert1, Steven P O'Hara, Nicholas F LaRusso
1Division of Gastroenterology and Hepatology and The Center for Cell Signaling (C-SiG), Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Current Opinion in Gastroenterology
|January 31, 2022
Summary
Cellular senescence is a key factor in inflammatory liver diseases like PSC and PBC. Targeting senescent cholangiocytes offers new therapeutic strategies for cholangiopathies.
Area of Science:
- Hepatology
- Cell Biology
- Pathology
Background:
- Cellular senescence, a permanent cell cycle arrest, is implicated in inflammatory liver diseases.
- Cholangiopathies, including PSC and PBC, share common pathological processes driven by cholangiocyte senescence.
Purpose of the Study:
- To review the role of cholangiocyte senescence in cholangiopathies.
- To discuss novel models, regulatory pathways, and therapeutic targets for cholangiopathies.
Main Methods:
- Literature review focusing on recent studies in cholangiocyte senescence and cholangiopathies.
- Analysis of key pathways and molecules regulating cholangiocyte senescence.
Main Results:
- Senescent cholangiocytes exhibit the senescence-associated secretory phenotype (SASP) and apoptosis resistance.
- Cholangiocyte senescence is a central pathogenetic process in cholestatic cholangiopathies like PSC and PBC.
Conclusions:
- Senescent cholangiocytes present novel prognostic and therapeutic targets for cholangiopathies.
- Understanding cholangiocyte senescence opens new avenues for basic research and clinical practice.
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