Related Experiment Video
Updated: Oct 5, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Environmental factors associated with gastric carcinogenesis
Violet Kayamba1, Paul Kelly1,2
1Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia.
Purpose Of Review:
Gastric cancer is one of the leading causes of cancer-related deaths globally. Several modifiable environmental factors have been linked to gastric carcinogenesis but in many cases, evidence is either weak or fragmented. In this review, we interrogate the latest evidence implicating environmental factors in the development of gastric cancer.
Recent Findings:
We are writing this review at a time when technological advancements are enabling scientists to effectively conduct large epidemiological studies with better tools for exposure estimations. We have highlighted risk factors that do not yet have enough evidence to be included as definite carcinogens in the International Agency for Research on Cancer monographs but have the potential for inclusion in the near future. Considered in our review are the links between gastric cancer and exposure to biomass smoke, particulate matter, occupational hazards and water contamination.
Summary:
This review illustrates the need for vigilance as evidence linking gastric cancer to various environmental factors is mounting. Many of these factors are modifiable, allowing for preventive strategies that could further decrease the global burden of gastric cancer.
Related Concept Videos
Cancer Prevention
Some...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

