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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
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Methamphetamine, neurotransmitters and neurodevelopment.

B Čechová1, R Šlamberová

  • 1Department of Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic. romana.slamberova@lf3.cuni.cz.

Physiological Research
|January 31, 2022
PubMed
Summary

Methamphetamine (MA) causes neurotoxicity by disrupting neurotransmission and oxidative stress, impacting the central nervous system (CNS). This review explores MA

Area of Science:

  • Neuroscience
  • Pharmacology
  • Toxicology

Background:

  • Methamphetamine (MA) is a widely abused psychoactive stimulant with significant neurotoxic properties.
  • MA abuse is linked to various neurological diseases due to its potent effects on the central nervous system (CNS).

Purpose of the Study:

  • This review aims to elucidate the mechanisms of MA-induced neurotoxicity.
  • Focus is placed on alterations in neurotransmission during the development of laboratory rats.
  • The review will also cover the development of neurotransmitters (NEUs) during critical developmental periods.

Main Methods:

  • Review of existing literature on methamphetamine neurotoxicity.
  • Analysis of animal research data, specifically focusing on laboratory rats.

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  • Examination of neurotransmitter (NEU) systems affected by MA.

    • Main Results:

    • MA exerts neurotoxic and degenerative effects through mechanisms like excessive neurotransmitter release and uptake transporter blockage.
    • MA intoxication can disrupt the blood-brain barrier via MA-induced oxidative stress.
    • MA alters neurotransmitter actions within the CNS, contributing to neurotoxicity.

    Conclusions:

    • Understanding MA's impact on neurotransmission is crucial for addressing its neurological consequences.
    • Developmental neurotoxicity of MA requires further investigation, particularly during critical growth periods.
    • MA-induced oxidative stress and blood-brain barrier disruption are key factors in its neurotoxic effects.