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Complex sympathetic regulation in adolescent mitral valve prolapse.
L Bona Olexova1, Z Visnovcova, N Ferencova
1Department of Physiology and Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic. ingrid.tonhajzerova@uniba.sk.
Physiological Research
|January 31, 2022
Summary
Adolescents with mitral valve prolapse (MVP) show enhanced cardiovascular sympathetic regulation, indicated by elevated blood pressure and altered heart rate variability. These findings suggest potential early biomarkers for MVP-related complications.
Area of Science:
- Cardiology
- Autonomic Nervous System Research
- Adolescent Health
Background:
- Mitral valve prolapse (MVP) can cause symptoms beyond mitral regurgitation.
- Autonomic dysfunction, particularly sympathetic overactivity, is implicated in MVP symptomatology.
- Non-invasive assessment of sympathetic function may offer diagnostic insights.
Purpose of the Study:
- To investigate sympathetic nervous system activity in adolescents with MVP.
- To evaluate non-invasive markers of cardiovascular sympathetic regulation in adolescent MVP patients.
- To explore potential early diagnostic biomarkers for MVP-related cardiovascular complications.
Main Methods:
- Compared 53 adolescents with MVP to 43 healthy controls.
- Measured blood pressure, heart rate variability, and electrodermal activity (EDA) at rest.
- Analyzed parameters including blood pressure variability, RR interval, symbolic dynamics (0V%), left ventricular ejection time (LVET), and pre-ejection period (PEP).
Main Results:
- MVP patients exhibited significantly higher systolic, diastolic, and mean blood pressure.
- Shortened mean RR interval and increased 0V% were observed in MVP patients.
- Reduced left ventricular ejection time (LVET) was noted in adolescents with MVP compared to controls.
Conclusions:
- Adolescent MVP patients demonstrate enhanced cardiovascular sympathetic regulation.
- Non-invasive sympathetic parameters may serve as early biomarkers for cardiovascular complications in adolescent MVP.
- Further evaluation of these parameters could aid in the early diagnosis and management of MVP.
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