Related Experiment Video
Updated: Oct 5, 2025
Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
[Pancytopenia and B-symptoms - an unexpected souvenir?]
Benjamin Gebel1, Jan Rupp1, Evelyn Kramme1
1Klinik für Infektiologie und Mikrobiologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck.
History:
The 79-year-old patient was admitted with recurring fever, weight loss, night sweat, a decrease in physical capacity and hematomas of the extremities.
Findings:
The patient presented with pancytopenia, elevated CRP and impaired renal function. A splenomegaly was evident in abdominal sonography. A bone marrow aspiration was performed.
Diagnosis:
Histopathologic examination revealed a visceral Leishmaniasis. The diagnosis was confirmed by PCR from peripheral blood.
Therapy And Course:
After initiation of liposomal amphotericin B haematopoiesis recovered and CRP decreased. Initially the renal function deteriorated with prolongated improvement in the course of therapy.
Conclusions:
Pancytopenia and corresponding symptoms are suspect for visceral Leishmaniasis also in patients supposed to be immunocompetent with travel history of endemic regions.
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