Progress in cancer drug delivery based on AS1411 oriented nanomaterials

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Cancer Research

Background:

• Targeted cancer therapy is crucial due to cancer's metastatic nature.
• AS1411 is a G-quadruplex aptamer with a unique four-chain structure.
• Research explores AS1411 modifications for enhanced cancer treatment strategies.

Purpose of the Study:

• To review research progress in cancer detection and drug delivery using modified AS1411 aptamers.
• To summarize AS1411 applications in cancer treatment and diagnostics.
• To highlight ongoing structural optimization and nanoparticle-based delivery systems.

Main Methods:

• Review of literature on AS1411 aptamer modifications.
• Analysis of AS1411 integration with nanomaterials (graphene, mesoporous silica, silver, gold).
• Examination of AS1411's role in active and passive targeting for cancer markers.

Main Results:

• Modified AS1411 aptamers show promise in cancer detection and drug delivery systems.
• AS1411 serves as a targeting agent for cancer markers like nucleoli.
• Nanoparticle modifications with AS1411 loaded with TCM extracts demonstrate further progress.

Conclusions:

• AS1411 aptamer modifications are vital for advancing targeted cancer therapy.
• Despite clinical trial discontinuation, AS1411 remains a significant area of research for novel drug delivery and diagnostics.
• Future research focuses on optimizing AS1411 structures and their integration with nanoparticles.