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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

462
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
462
Brain Imaging01:14

Brain Imaging

362
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
362

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Related Experiment Video

Updated: Oct 5, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Developmental brain structural atypicalities in autism: a voxel-based morphometry analysis.

Hui Wang1, Zeng-Hui Ma1, Ling-Zi Xu1

  • 1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 51 Huayuan Road, Haidian District, Beijing, 100191, China.

Child and Adolescent Psychiatry and Mental Health
|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Autism spectrum disorder (ASD) shows varied regional gray matter changes across development. These brain structural differences highlight the importance of considering age in autism research.

Keywords:
AutismBrain structural atypicalitiesVoxel-based morphometrysMRI

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Radiology

Background:

  • Autism spectrum disorder (ASD) is associated with brain structural atypicalities.
  • Previous structural magnetic resonance imaging (sMRI) studies show inconsistent findings, necessitating further investigation.

Purpose of the Study:

  • To investigate atypical structural brain features in autistic individuals aged 6-30 years.
  • To compare brain structure between autistic and typically developing (TD) individuals across developmental stages.

Main Methods:

  • Included 52 autistic and 50 TD individuals, matched for age, gender, and IQ.
  • Data analyzed across three cohorts: childhood (6-12), adolescence (13-18), and adulthood (19-30).
  • Employed sMRI for whole-brain volume and voxel-based morphometry (VBM) analyses.

Main Results:

  • No significant differences in whole-brain, gray matter, or white matter volumes were found between groups across cohorts.
  • VBM revealed age-specific regional gray matter differences: smaller volumes in the right superior temporal gyrus and right inferior parietal lobule in autistic children (6-12).
  • Larger gray matter volume in the left inferior parietal lobule in autistic adolescents (13-18), and in the right middle occipital gyrus in autistic adults (19-30). Smaller volume in the left posterior cingulate gyrus was also noted in adults.

Conclusions:

  • Autistic individuals exhibit distinct regional gray matter volumetric changes during childhood, adolescence, and adulthood compared to TD peers.
  • Developmental stage is a critical factor when examining brain structural atypicalities in autism spectrum disorder.