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Heparin 1986. Indications and effective use.

P Ockelford

    Drugs
    |January 1, 1986
    PubMed
    Summary

    Heparin, a complex polysaccharide, prevents blood clots by enhancing antithrombin III

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    Area of Science:

    • Pharmacology
    • Hematology

    Background:

    • Heparin is a complex polysaccharide that acts as an anticoagulant.
    • It potentiates antithrombin III inhibition of activated clotting proteins.

    Purpose of the Study:

    • To review the indications, administration, and monitoring of heparin therapy.
    • To discuss the use of heparin in venous and arterial thromboembolism, and disseminated intravascular consumption (DIC).

    Main Methods:

    • Review of existing literature on heparin's clinical applications.
    • Discussion of monitoring methods including activated partial thromboplastin time (APTT) and chromogenic assays.
    • Consideration of prophylactic and therapeutic regimens for various thromboembolic conditions.

    Main Results:

    • Heparin is indicated for venous thromboembolic disease, arterial thromboembolism, and symptomatic DIC complications.
    • Monitoring typically involves APTT, with chromogenic assays useful in specific cases like pregnancy or lupus anticoagulant.
    • Low molecular weight heparin shows promise in minimizing bleeding complications.

    Conclusions:

    • Heparin is a vital anticoagulant with broad applications in thromboembolic disorders.
    • Appropriate monitoring and consideration of side effects are crucial for effective heparin therapy.
    • Ongoing research into modified heparin forms aims to improve safety and efficacy.

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