Lipid nanotubes: Formation and applications

Lipids, the fundamental components of cell membrane, play important roles in the whole cycle of cell life, thus attracting worldwide attention, owing to their physicochemical property and extensive use in the applications based on lipid assemblies. Compared with liposomes, lipid nanotubes (LNTs) usually possess unique properties, such as highly ordered structure, precise molecular recognition, and the possibility of substance transport, thus providing more potential applications in different research fields. However, until now, there are still quite rare cases of LNTs successfully employed in practical applications. Bearing this in mind and based on our own experience in this field, we summarized and discussed the recent progress of the fabrication approaches and representative applications of the LNTs in the past decade, which would potentially provide basic understanding and guidance towards their future development.