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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Oct 5, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Proteomics in uveal melanoma.

Michael J Heiferman^1,2, Vinit B Mahajan^2,3, Prithvi Mruthyunjaya^2,4

¹Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois.

Current Opinion in Ophthalmology

|February 1, 2022

Summary

Proteomic analysis advances understanding of uveal melanoma pathophysiology and identifies biomarkers for diagnosis, prognosis, and treatment. This research offers improved patient outcomes through personalized management strategies.

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Area of Science:

Ophthalmology
Oncology
Proteomics

Background:

Uveal melanoma is the most common primary intraocular malignancy.
Accurate diagnosis, prognostication, and treatment are crucial for patient outcomes.

Purpose of the Study:

To review the latest proteomic research on uveal melanoma.
To highlight the role of proteomics in understanding uveal melanoma pathophysiology.
To identify potential biomarkers and therapeutic targets.

Main Methods:

Review of recent proteomic studies on uveal melanoma.
Analysis of proteomic data from cell lines, tissue specimens, and biofluids (serum, aqueous, vitreous).

Main Results:

Proteomic analysis enhances understanding of uveal melanoma pathophysiology.
Identification of potential prognostic biomarkers from tissue and serum.
Aqueous and vitreous humor proteomes offer safer biomarkers for metastatic risk and therapeutic targets.
Proteomics aids in diagnosis, prognostication, surveillance, and treatment.

Conclusions:

Proteomic analysis is vital for understanding uveal melanoma.
Proteomics facilitates personalized management and improved patient outcomes.