Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

1.2K
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
1.2K
Uterus and Cervix01:18

Uterus and Cervix

2.4K
The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs...
2.4K
Ovarian Cycle01:27

Ovarian Cycle

2.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
2.1K
Histology of the Uterus01:19

Histology of the Uterus

2.2K
The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
2.2K
Menses Phase01:18

Menses Phase

494
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
494
Infertility in Females01:28

Infertility in Females

1.3K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tranexamic acid use for the prevention of postpartum hemorrhage in high-income countries: a review of recent literature.

AJOG global reports·2026
Same author

Pathology Following Stillbirth: Differences by Insurance Status and Educational Attainment.

Paediatric and perinatal epidemiology·2026
Same author

Double dural puncture epidural; once is more than enough.

European journal of anaesthesiology·2026
Same author

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation.

The Journal of physiology·2026
Same author

Trends in fetal autopsy and placental histopathology following stillbirth, United States, 2014-2023.

Journal of perinatology : official journal of the California Perinatal Association·2025
Same author

Vascular effects of a hypertensive disorder of pregnancy antepartum and postpartum: the EPOCH study.

American journal of obstetrics & gynecology MFM·2025
Same journal

Management of hypertensive disorders in pregnancy.

Current opinion in obstetrics & gynecology·2026
Same journal

Updates in group prenatal care research.

Current opinion in obstetrics & gynecology·2026
Same journal

Complex benign gynecology in perimenopause: current evidence and future directions.

Current opinion in obstetrics & gynecology·2026
Same journal

Role of insulin in female reproduction.

Current opinion in obstetrics & gynecology·2026
Same journal

Urinary tract involvement in endometriosis: current evidence and clinical insights into navigating diagnosis and management.

Current opinion in obstetrics & gynecology·2026
Same journal

Updates in ultrasound imaging of adenomyosis and clinical impacts.

Current opinion in obstetrics & gynecology·2026
See all related articles

Related Experiment Video

Updated: Oct 5, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

512

Uterine atony.

Hayley E Miller1, Jessica R Ansari2

  • 1Division of Maternal-Fetal Medicine and Obstetrics, Department of Obstetrics and Gynecology, Stanford University School of Medicine.

Current Opinion in Obstetrics & Gynecology
|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Postpartum hemorrhage (PPH) due to uterine atony is increasing globally. Current treatments show limited efficacy, highlighting an urgent need for new, controlled studies to combat this leading cause of maternal mortality.

More Related Videos

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

16.8K
Development of a Uterosacral Ligament Suspension Rat Model
08:58

Development of a Uterosacral Ligament Suspension Rat Model

Published on: August 17, 2022

4.4K

Related Experiment Videos

Last Updated: Oct 5, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

512
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

16.8K
Development of a Uterosacral Ligament Suspension Rat Model
08:58

Development of a Uterosacral Ligament Suspension Rat Model

Published on: August 17, 2022

4.4K

Area of Science:

  • Obstetrics and Gynecology
  • Maternal Health
  • Critical Care Medicine

Background:

  • Postpartum hemorrhage (PPH) is a major global cause of maternal morbidity and mortality.
  • Uterine atony accounts for up to 80% of PPH cases.
  • Rising PPH rates necessitate updated reviews of uterine atony management.

Purpose of the Study:

  • To provide a contemporary review of uterine atony.
  • To cover epidemiology, risk factors, pathophysiology, and treatment of uterine atony.

Main Methods:

  • Literature review of recent studies on uterine atony and PPH.
  • Analysis of current treatment protocols and emerging interventions.
  • Evaluation of a new uterine tone assessment score.

Main Results:

  • Uterine atony remains the primary driver of increasing PPH rates.
  • Oxytocin prophylaxis requires careful dosing, with variations based on patient factors.
  • Carbetocin is a viable alternative; misoprostol shows limited efficacy for atony.
  • Novel mechanical and surgical treatments are emerging but require further study.

Conclusions:

  • There is a critical need for rigorous, controlled clinical trials.
  • Developing effective strategies against atonic PPH is paramount.
  • Standardized assessment tools may aid future research and clinical practice.