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Updated: Oct 5, 2025
07:55
Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
Published on: June 2, 2023
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TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import
Aloke K Bera1, Runrun Wu2, Simone Harrison3
1Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Communications Biology
|February 1, 2022
Abstract:
To combat nutritional immunity, N. gonorrhoeae has evolved systems to hijack zinc and other metals directly from host metal-binding proteins such as calprotectin (CP). Here, we report the 6.1 Å cryoEM structure of the gonococcal surface receptor TdfH in complex with a zinc-bound CP tetramer. We further show that TdfH can also interact with CP in the presence of copper and manganese, but not with cobalt.
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