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Tailoring Niosomes- Implications for Controlled Cargo Release and Function as Nanoreactors.

Sudeshna Sarkar1, Swati De2

  • 1Department of Chemistry, University of Kalyani, Kalyani, West Bengal, 741235, India.

Journal of Fluorescence
|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Nonionic surfactant vesicles (niosomes) were developed using Brij 58 and cholesterol. These niosomes effectively encapsulated gold nanoparticles and demonstrated potential as drug delivery vehicles, with fluorescence studies providing insights into their structure and applications.

Keywords:
Cargo releaseFRETGNPsNanoreactorsNiosomes

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Nonionic surfactant vesicles, or niosomes, are versatile self-assembled structures with potential in drug delivery and nanoreactor applications.
  • Understanding the structural integrity and behavior of niosomes under varying conditions is crucial for optimizing their performance.
  • The cell membrane-mimicking nature of niosomal bilayers makes them attractive platforms for biological and therapeutic applications.

Purpose of the Study:

  • To investigate the effect of Brij 58:cholesterol molar ratios on niosomal structure and integrity.
  • To evaluate the efficacy of niosomes as drug release vehicles using Carboxyfluorescein (CF).
  • To explore the use of niosomes as nanoreactors for synthesizing gold nanoparticles (GNPs) and assess their potential for diagnostic and therapeutic applications.

Main Methods:

  • Niosomes were prepared using polyoxyethylene alkyl ether (Brij 58) and cholesterol.
  • Fluorescence spectroscopy with 1,6-Diphenyl-1,3,5-triene (DPH) was employed to study bilayer integrity.
  • Carboxyfluorescein (CF) release studies were conducted to assess drug delivery potential.
  • Gold nanoparticles (GNPs) were synthesized within the niosomes, and their properties were characterized.
  • Fluorescence resonance energy transfer (FRET) between DPH and CF was analyzed.

Main Results:

  • Varying the Brij 58:cholesterol molar ratio influenced niosomal structure and bilayer integrity.
  • Niosomes demonstrated controlled release of Carboxyfluorescein, indicating potential as drug delivery vehicles.
  • Stable, spherical gold nanoparticles (6-10 nm diameter) were successfully synthesized within the niosomal nanoreactors.
  • Fluorescence resonance energy transfer (FRET) was observed between DPH and CF, providing insights into dye localization within the vesicles.

Conclusions:

  • Niosomes, prepared with Brij 58 and cholesterol, exhibit tunable structural properties and serve as effective nanoreactors for GNP synthesis.
  • The niosomal system shows promise for controlled drug release and the development of GNPs for diagnostic and therapeutic applications.
  • FRET studies offer a valuable method for tracking probe location in biomimicking systems, with potential extrapolation to in vivo applications.