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The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

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Related Experiment Video

Updated: Oct 5, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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The EXTrauterine Environment for Neonatal Development: Present and Future.

Abby C Larson1, Felix R De Bie1,2, Jonathan Chang1

  • 1Center for Fetal Research, 6567Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|February 1, 2022
PubMed
Summary

Researchers developed the EXTrauterine Environment for Neonatal Development (EXTEND) system to support premature lambs. This fluidic system mimics the womb, showing promise for improving outcomes in extreme prematurity.

Keywords:
EXTra-uterine environment for neonatal developmentartificial placentaartificial wombprematureprematurity

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Area of Science:

  • Neonatal development
  • Perinatal medicine
  • Bioengineering

Background:

  • Extreme prematurity presents significant challenges in neonatal care.
  • Existing methods for supporting premature infants have limitations.
  • Mimicking the natural fetal environment is crucial for improving outcomes.

Purpose of the Study:

  • To describe the development of the EXTrauterine Environment for Neonatal Development (EXTEND) system.
  • To review the use of EXTEND in supporting premature lamb development.
  • To discuss the potential clinical translation of this technology.

Main Methods:

  • Development of a novel fluidic support system (EXTEND).
  • Utilizing a premature lamb model to test the EXTEND system.
  • Review of existing literature on fetal development and support.

Main Results:

  • The EXTEND system successfully supported fetal growth in the premature lamb model.
  • The fluidic environment mimicked natural fetal circulation.
  • This approach shows promise for long-term support.

Conclusions:

  • The EXTrauterine Environment for Neonatal Development (EXTEND) offers a novel approach to support extreme prematurity.
  • This technology has the potential to significantly improve outcomes for premature infants.
  • Further research and clinical translation are warranted.