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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Databases for intrinsically disordered proteins.

Damiano Piovesan1, Alexander Miguel Monzon1, Federica Quaglia1

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|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Intrinsically disordered regions (IDRs) are crucial for cell regulation but poorly understood. This study overviews available resources, analyzing their scope and relevance for structural biology research.

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databasesflexible proteinsintrinsically disordered proteinsprotein ensembles

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Area of Science:

  • Structural biology
  • Cellular regulation
  • Biochemistry

Background:

  • Intrinsically disordered regions (IDRs) lack fixed 3D structures and are vital for cellular regulation.
  • Functional characterization of IDRs is limited, with scattered experimental data.
  • Predicting and characterizing IDRs remain challenging.

Purpose of the Study:

  • To provide a comprehensive overview of publicly available knowledge on IDRs.
  • To analyze the types, scopes, and availability of IDR resources.
  • To compare the volume and relevance of information for structural biology.

Main Methods:

  • Literature review of manually curated resources.
  • Analysis of deposition databases for IDR data.
  • Examination of IDR prediction repositories.
  • Comparative analysis of resource complementarity and overlap.

Main Results:

  • Identified and categorized various public resources for IDRs.
  • Assessed the scope, accessibility, and content of each resource type.
  • Highlighted the strengths and limitations of current IDR knowledge repositories.
  • Compared the utility of different resources for structural biology.

Conclusions:

  • Publicly available resources for intrinsically disordered regions are diverse but fragmented.
  • A systematic analysis reveals gaps and overlaps in current IDR knowledge bases.
  • Understanding these resources is crucial for advancing IDR research and structural biology.
  • Further integration and curation of IDR data are needed.