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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Profile of Microbial Keratitis.

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  • 1Ophthalmology, Taiping Hospital, Perak, MYS.

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This study found that corneal foreign bodies are a common cause of microbial keratitis, often leading to good visual outcomes. However, complications and specific bacteria like Pseudomonas sp. are linked to poor visual prognosis.

Keywords:
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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Epidemiology

Background:

  • Microbial keratitis is a significant cause of visual impairment worldwide.
  • Understanding regional demographic and etiological trends is crucial for effective management.

Purpose of the Study:

  • To investigate demographic factors, predisposing causes, and causative organisms in microbial keratitis.
  • To identify prognostic indicators for visual outcomes in affected patients.

Main Methods:

  • A retrospective analysis of 75 eyes from 74 patients admitted with microbial keratitis between January 2018 and December 2020.
  • Data collected included patient demographics, predisposing factors, microbiological results, complications, and visual outcomes.

Main Results:

  • The majority of patients (70%) were aged 20-59, with a male predominance (13.8:1).
  • Corneal foreign bodies were the most frequent predisposing factor (56%), associated with favorable visual outcomes.
  • Gram-negative bacteria, particularly Pseudomonas sp. (26.7%), were the leading cause, linked to poor outcomes, especially in contact lens wearers. Complications like corneal melting, perforation, and endophthalmitis significantly worsened visual prognosis.

Conclusions:

  • Microbial keratitis disproportionately affects the working-age population.
  • Prompt identification of causative agents and risk factors, such as Pseudomonas sp., is vital for improving visual outcomes.
  • Early and appropriate treatment, considering predisposing factors and complications, can mitigate ocular morbidity.