Early motor repertoire and neurodevelopment at 2 years in infants born extremely preterm or extremely-low-birthweight

Amanda K L Kwong1,2,3, Lex W Doyle1,2,4,5, Joy E Olsen1,2

  • 1Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Insights

Early motor assessments in extremely preterm infants can predict later neurodevelopmental outcomes. Poorer scores on the Motor Optimality Score-Revised (MOS-R) and abnormal General Movements Assessment (GMA) at 14 weeks corrected age are linked to cerebral palsy and developmental delays at two years.

Area of Science:

  • Neonatal neurology
  • Developmental pediatrics
  • Movement science

Background:

  • Infants born extremely preterm (<28 weeks' gestation) or extremely-low-birthweight (ELBW) (<1000g) are at high risk for neurodevelopmental impairments.
  • Early identification of neurodevelopmental risks is crucial for timely intervention.

Purpose of the Study:

  • To investigate the relationship between early motor repertoire and neurodevelopmental outcomes at two years in extremely preterm/ELBW infants.
  • To assess the predictive value of the General Movements Assessment (GMA) and Motor Optimality Score-Revised (MOS-R) for neurodevelopmental outcomes.

Main Methods:

  • A prospective cohort study of 139 extremely preterm/ELBW infants was conducted.
  • Parent-recorded videos were used to score the GMA and MOS-R at 12-13 and 14-15 weeks corrected age.
  • Neurodevelopmental outcomes at two years included cerebral palsy diagnosis and scores on the Bayley Scales of Infant and Toddler Development.

Main Results:

  • Higher MOS-R scores at 14-15 weeks corrected age were associated with lower odds of cerebral palsy (CP) and motor or cognitive impairment at two years.
  • Absent or abnormal GMA at 14-15 weeks corrected age predicted CP and motor delay.
  • Early MOS-R scores (12-13 weeks) showed limited association with two-year neurodevelopmental outcomes.

Conclusions:

  • Motor repertoire assessments, specifically MOS-R and GMA, at 14-15 weeks corrected age are valuable predictors of neurodevelopmental outcomes in extremely preterm/ELBW infants.
  • These findings support the use of early motor assessments for identifying infants at risk for CP and developmental impairments.
Abstract

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