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Updated: Oct 5, 2025
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Failed Breast Conservation Therapy Predicts Higher Frequency of Revision Surgery following Mastectomy with
Danielle H Rochlin1, Clifford C Sheckter1, Arash Momeni1
1From the Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Palo Alto, Calif.
Background:
Breast conservation therapy remains the gold standard for women with localized breast cancer; however, some women may eventually undergo mastectomy with reconstruction. Little is understood regarding the risks of failed breast conservation therapy as they relate to postmastectomy reconstruction and whether this affects outcomes.
Methods:
Patients undergoing breast reconstruction were extracted from the IBM MarketScan Commercial Database from 2007 to 2016. Frequency of lumpectomy and radiation therapy were determined per reconstructive patient. Outcomes included inpatient complications and frequency of revision procedures. Regression models were adjusted for age, obesity, timing of reconstruction, and Elixhauser Comorbidity Index.
Results:
Six thousand two hundred eighty-eight of 52,826 (11.9 percent) women underwent one or more breast mass excisions before mastectomy with reconstruction. Of those, the mean number of excisions per woman was 1.67 ± 0.90. There were 3334 lumpectomy patients (53.0 percent) who completed radiation therapy. The mean number of revisions with breast conservation therapy was 1.5 versus 1.3 in the general cohort. On multivariable analysis, excision of breast mass alone was not associated with increased odds of inpatient complications (OR, 1.07; p = 0.363), nor was radiation therapy (OR, 0.89; p = 0.153). However, radiation therapy with or without excision of breast mass before mastectomy was a significant predictor of more frequent revision operations (p = 0.032). Excision of breast mass alone was not associated with an increased frequency of revision (p = 0.173).
Conclusions:
History of radiation therapy in the setting of failed breast conservation therapy resulting in mastectomy with reconstruction was associated with an increased risk for revision. Patients should be counseled accordingly before breast conservation therapy in the event they may eventually undergo mastectomy with reconstruction.
Clinical Question/Level Of Evidence:
Therapeutic, III.
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