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Related Concept Videos

Anatomy of the Ear01:16

Anatomy of the Ear

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Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
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A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

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Tissue engineering of human ear pinna.

Nilesh Bhamare1, Kishor Tardalkar2, Archana Khadilkar3

  • 1Department of Stem Cells and Regenerative Medicine, D. Y. Patil Education Society (Deemed to be University), Kasaba Bawada, 416 006, Kolhapur, Maharashtra, India. nilesh.foodbiochem@gmail.com.

Cell and Tissue Banking
|February 1, 2022
PubMed
Summary

Tissue engineering offers a solution for ear deformities like microtia. Molding and 3D printing successfully created patient-specific ear scaffolds, showing promising results for clinical applications.

Keywords:
3D printingAuricular deformitiesBiofabricationBioinkClinical treatmentsExtracellular matrixScaffoldTissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Auricular deformities (microtia) significantly impact patient well-being.
  • Current biofabrication methods lack precision for complex ear structures.
  • Tissue engineering presents a viable solution to overcome these limitations.

Purpose of the Study:

  • To biofabricate a flexible, human-size ear pinna using molding and 3D printing.
  • To evaluate the biocompatibility and regenerative potential of engineered ear constructs.

Main Methods:

  • Decellularization of goat ear cartilage and bioink alkaline digestion to create scaffolds.
  • Utilized molding technology and 3D printing (CAD/STL) with bioink for patient-specific ear construction.
  • Assessed in vivo biocompatibility, recellularization, mechanical properties, and angiogenesis in a rat model.

Main Results:

  • Both molding and 3D printing techniques successfully generated ear pinnae with suitable mechanical properties.
  • Histology and SEM confirmed recellularization by cartilage-specific cells and ECM development post-transplantation.
  • Demonstrated successful angiogenesis in the molded ear pinna and acceptance of the xenograft by the host.

Conclusions:

  • Tissue-engineered ear pinnae fabricated via molding and 3D printing are biocompatible and promote regeneration.
  • These techniques show potential for creating patient-specific auricular implants.
  • Successful transplantation in an animal model paves the way for clinical applications in treating microtia.