Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

73
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
73
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

234
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
234
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.6K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.6K
Coronary Circulation01:21

Coronary Circulation

4.7K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
4.7K
Obesity01:24

Obesity

671
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
671
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

56
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
56

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seven-Year Valve Durability With Transcatheter or Surgical Aortic Valve Replacement: An Ad Hoc Analysis of the PARTNER 3 Randomized Clinical Trial.

JAMA cardiology·2026
Same author

<sup>18</sup>F-FDG -PET/CT in cardiac sarcoidosis: Diagnosis, therapy monitoring, and future directions.

Seminars in nuclear medicine·2026
Same author

Residual Angina Following Complete Revascularization in the ISCHEMIA Trial: Frequency, Clinical Characteristics, Health Status, and Cardiovascular Outcomes.

Journal of the American Heart Association·2026
Same author

Temporal Trends in Direct-Acting Oral Anticoagulants Use Among Patients at Extremes of Body Weight: Insight From PINNACLE Registry.

Mayo Clinic proceedings. Innovations, quality & outcomes·2026
Same author

Pediatric thyroid cancer lung metastases and RAI: long-term results.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same author

Assessment of CCR2 PET as a Biomarker for Head and Neck Squamous Cell Carcinoma.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Related Experiment Video

Updated: Oct 5, 2025

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
08:58

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

9.7K

Coronary circulatory function with increasing obesity: A complex U-turn.

Anand Upadhyaya1,2, Anita Bhandiwad2, Jordan Lang1

  • 1Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.

European Journal of Clinical Investigation
|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Coronary blood flow decreases with increasing body weight in overweight and obese individuals. However, morbid obesity shows a U-turn, with flow returning to normal levels, suggesting distinct underlying mechanisms.

Keywords:
adipocytokinesbody weightcoronary circulationmorbid obesitymyocardial blood flowmyocardial flow reserveobesitypositron emission tomography

More Related Videos

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.1K
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
07:24

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

7.6K

Related Experiment Videos

Last Updated: Oct 5, 2025

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
08:58

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

9.7K
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.1K
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
07:24

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

7.6K

Area of Science:

  • Cardiovascular Physiology
  • Obesity Medicine
  • Medical Imaging

Background:

  • Coronary circulatory function can be affected by increasing body weight.
  • Metabolically unhealthy obesity presents unique challenges in cardiovascular risk management.
  • Understanding these alterations is crucial for personalized patient care.

Purpose of the Study:

  • To investigate and characterize changes in coronary circulatory function related to increasing body weight.
  • To explore the impact of metabolically unhealthy obesity on myocardial blood flow.
  • To differentiate the effects of varying degrees of obesity on cardiovascular health.

Main Methods:

  • Prospective enrollment of 106 patients with suspected coronary artery disease (CAD).
  • Utilized 13N-ammonia PET/CT to assess myocardial blood flow (MBF) at rest and during hyperemia.
  • Categorized patients into normal weight, overweight, obese, and morbidly obese groups based on BMI.

Main Results:

  • Resting MBF remained comparable across all BMI groups.
  • Hyperemic MBF progressively decreased in overweight and obese groups compared to normal weight.
  • A U-turn pattern was observed, with hyperemic MBF increasing in the morbidly obese group, similar to normal weight individuals.
  • BMI showed a quadratic correlation with hyperemic MBF.

Conclusions:

  • The observed U-turn in hyperemic MBF from obesity to morbid obesity suggests distinct pathophysiological mechanisms.
  • Contrasting effects of abdominal versus subcutaneous adipose tissue may influence coronary circulatory function.
  • These findings indicate potentially different disease entities within obesity requiring further investigation.