Electro-Oxidative sp3 C-H Bond Functionalization and Annulation Cascade: Synthesis of Novel Heterocyclic Substituted
Bhanwar Kumar Malviya1, Amanpreet Kaur Jassal2, Manvika Karnatak3
1Department of Chemistry, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, India.
Abstract:
Indolizine derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we report a novel electro-oxidative cascade cyclization reaction that uses electricity as the primary energy input to promote the reaction, leading to a series of heterocyclic substituted indolizine derivatives under exogenous-oxidant-free conditions. It is noteworthy that this electrochemical method provides a novel strategy for generating heterocyclic diversity of quinazolinones and quinolines on indolizines. In addition, the sole byproduct in the reaction was molecular hydrogen.
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