Validation of a preeclampsia early screening test in a Mexican population

No preeclampsia screening test has been validated in our country.

To assess the fit and performance of the FMF 4.0 Bayesian algorithm in a Mexican population.

Cohort study in singleton pregnancies, according to the competing risks model for preeclampsia. A priori risk was calculated based on medical history. Mean blood pressure (MBP), uterine artery mean pulsatility index (UtAmPI) and pregnancy-associated plasma protein A (PAPP-A) were measured at 11-14 weeks of gestation using standardized methodology. The value of each marker was transformed into multiples of the median (MoM) by the original_a algorithm and by population-correction_b. Multivariate normal distribution and Bayes theorem were applied to obtain post-test probabilities.

There was 5.0% (40/807) of preeclampsia. Distributions in women without preeclampsia were MBP = 0.927_a vs. 0.991_b, UtAmPI = 0.895_a vs. 1.030_b and PAPP-A = 0.815_a vs. 0.963_b (p < 0.001). The AUC was 0.821_a vs. 0.823_b. For a detection rate of 69 %, cutoff points were 1 in 240_a and 1 in 120_b, with false positive rates of 31 %_a and 29 %_b.

The model has to be adjusted to the target population.