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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Burn Injuries01:22

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Updated: Oct 5, 2025

Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally
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Disseminated Mycobacterium abscessus Infection in a Burn Patient.

Emily H Hsu1, Sierra Young1, Nicola Clayton1

  • 1Department of Pharmacy, UC Davis Health, Sacramento, California, USA.

Journal of Burn Care & Research : Official Publication of the American Burn Association
|February 1, 2022
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Disseminated nontuberculous mycobacteria (NTM) infection is rare, especially in burn patients. This case highlights a successful oral treatment transition for Mycobacterium abscessus bacteremia in a severe burn patient.

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Burn Surgery

Background:

  • Nontuberculous mycobacteria (NTM) disseminated infections are rare, primarily affecting severely immunocompromised individuals.
  • Burn injuries compromise the cutaneous barrier and induce immune dysfunction, increasing susceptibility to infections, including multidrug-resistant organisms.
  • NTM infections in burn patients are infrequently reported and challenging to diagnose due to overlapping symptoms like hyperpyrexia.

Observation:

  • A critically ill burn patient with extensive (74% total body surface area) burns developed disseminated infection with bacteremia.
  • The causative agent was identified as Mycobacterium abscessus, a rapidly growing, often drug-resistant NTM species.
  • This represents the third reported case of NTM bacteremia in a burn patient.

Findings:

  • The case details the diagnostic challenges of disseminated NTM infection in the context of severe burn physiology.
  • Successful transition from intravenous to oral antimicrobial therapy was achieved for Mycobacterium abscessus bacteremia.
  • This is the second reported instance of successful oral regimen transition for NTM bacteremia in a burn patient.

Implications:

  • Highlights the importance of considering NTM infections in burn patients, even with atypical presentations.
  • Demonstrates the feasibility of oral antimicrobial therapy for NTM bacteremia in selected burn patients.
  • Contributes to the limited literature on managing rare disseminated NTM infections in critical care settings.