Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 5, 2025

Micro-drive Array for Chronic in vivo Recording: Drive Fabrication
14:03

Micro-drive Array for Chronic in vivo Recording: Drive Fabrication

Published on: April 20, 2009

25.4K

Rewritable Macromolecular Data Storage with Automated Read-out.

Matthieu Soete1, Kevin De Bruycker1, Filip Du Prez1

  • 1Polymer Chemistry Research group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S4-bis, 9000, Ghent, Belgium.

Angewandte Chemie (International Ed. in English)
|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly robust molecular information carriers for traceability of plastic materials.

Nature communications·2026
Same author

Tailoring fully biobased optical adhesives <i>via</i> hydrogen-bonding modulation.

RSC applied polymers·2026
Same author

Acrylic Hot-Melt Adhesives Containing Dynamic Covalent Cross-Links.

ACS macro letters·2026
Same author

Enhancing Debonding of Epoxy-Based Structural Adhesives with Hybrid Dynamic Curing Agents.

ACS applied materials & interfaces·2026
Same author

Low-Viscosity, Dynamic Amidoamine Hardeners with Tunable Curing Kinetics for Epoxy Adhesives.

Macromolecules·2026
Same author

Chemical Upcycling of Polybutadiene Into Polyolefin-Based Dynamic Covalent Polymer Networks.

Macromolecular rapid communications·2025

Researchers developed a reversible method to rewrite data on synthetic macromolecules and an algorithm, Oligoreader, for easier data retrieval using mass spectrometry, advancing digital macromolecule capabilities.

Area of Science:

  • Synthetic biology
  • Biotechnology
  • Data storage

Background:

  • Storing digital data on synthetic macromolecules is challenging.
  • Previous methods for data encoding and retrieval on macromolecules were limited.

Purpose of the Study:

  • To develop a reversible method for modifying sequence-encoded macromolecule data.
  • To create an algorithm for simplifying the readout of macromolecular information using mass spectrometry.

Main Methods:

  • A strategy for reversible modification of position tags on sequence-encoded macromolecules using orthogonal cleavage of a thioester moiety via aminolysis.
  • Development of a novel algorithm, Oligoreader, for analyzing MS1 and MS2 spectra to decode macromolecular data.
  • Demonstration of the modification method using an exemplary sentence.
Keywords:
Automated Read-outMolecular Data StorageOligoreaderRewriting DataSequence-Defined Macromolecules

More Related Videos

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

16.6K
An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
07:55

An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering

Published on: July 6, 2019

13.4K

Related Experiment Videos

Last Updated: Oct 5, 2025

Micro-drive Array for Chronic in vivo Recording: Drive Fabrication
14:03

Micro-drive Array for Chronic in vivo Recording: Drive Fabrication

Published on: April 20, 2009

25.4K
Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

16.6K
An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
07:55

An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering

Published on: July 6, 2019

13.4K

Main Results:

  • Successfully demonstrated reversible modification of sequence-encoded macromolecules.
  • Oligoreader algorithm can identify, analyze, and decode data from MS spectra.
  • The algorithm automates data readout, minimizing operator interference for blind sequencing.

Conclusions:

  • The developed method allows for reversible data rewriting on synthetic macromolecules.
  • Oligoreader significantly simplifies and enhances the process of retrieving information from macromolecules.
  • These advancements hold potential for improved digital data storage and sequencing applications.