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Predictors for early mortality in patients with implantable cardiac defibrillator for heart failure with reduced

Göksel Çinier1, Mert İlker Hayıroğlu1, Tufan Çınar2

  • 1Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Indian Heart Journal
|February 1, 2022
PubMed

Insights

This study identified key risk factors for one-year mortality in heart failure patients with reduced ejection fraction (HFrEF) receiving an implantable cardioverter defibrillator (ICD). Understanding these predictors can improve patient outcomes and guide clinical decisions.

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Research

Background:

  • Implantable cardioverter defibrillators (ICDs) are crucial for managing arrhythmic deaths in heart failure with reduced ejection fraction (HFrEF).
  • Identifying patients at higher risk of mortality post-ICD implantation is essential for personalized care.

Purpose of the Study:

  • To determine the independent risk factors associated with one-year mortality in HFrEF patients following ICD implantation.
  • To provide data that can aid in risk stratification and clinical decision-making for HFrEF patients undergoing ICD procedures.

Main Methods:

  • Retrospective analysis of 1107 HFrEF patients who received ICDs between 2009 and 2019.
  • Data extracted from a hospital's electronic database.
  • Multivariate analysis to identify independent predictors of one-year mortality.

Main Results:

  • The overall one-year mortality rate following ICD implantation was 4.7%.
  • Independent predictors of one-year mortality included older age, atrial fibrillation, advanced New York Heart Association (NYHA) classification (>2), elevated blood urea nitrogen (BUN), higher pro-brain natriuretic peptide (BNP) levels, and lower serum albumin.

Conclusions:

  • Several clinical and laboratory parameters independently predict one-year mortality in HFrEF patients after ICD implantation.
  • These findings highlight the importance of comprehensive risk assessment in this patient population to optimize management strategies and improve survival rates.

Keywords:
Early mortalityHeart failure with reduced ejection fractionImplantable cardiac defibrillator

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