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Related Experiment Video

Updated: Oct 5, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Multi-omics research in sarcopenia: Current progress and future prospects.

Jia-Chen Liu1, Shan-Shan Dong2, Hui Shen3

  • 1School of Basic Medical Science, Central South University, Changsha, PR China.

Ageing Research Reviews
|February 1, 2022
PubMed
Summary
This summary is machine-generated.

Sarcopenia, an age-related muscle disease, involves complex genetic factors. Integrative multi-omics studies are crucial for understanding its causes and developing new treatments.

Keywords:
EpidemiologyGenomicsMetabolomicsProteomicsSarcopeniaTranscriptomics

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Area of Science:

  • Gerontology
  • Muscle Physiology
  • Genetics

Background:

  • Sarcopenia is a progressive skeletal muscle disorder characterized by decreased muscle mass and function.
  • While heritability is known, the genetic architecture and molecular basis of sarcopenia remain largely undefined.
  • Genome-wide association studies have identified some susceptibility loci.

Purpose of the Study:

  • To review recent multi-omics findings related to sarcopenia.
  • To summarize current understanding of sarcopenia pathogenesis.
  • To highlight the potential of integrative multi-omics analyses for uncovering new insights.

Main Methods:

  • Review of recent literature on multi-omics studies (genomics, epigenomics, transcriptomics, proteomics, metabolomics) in sarcopenia.
  • Synthesis of findings from individual omics technologies and integrative approaches.
  • Analysis of current understanding of sarcopenia etiology and pathophysiology.

Main Results:

  • Advances in omics techniques offer new avenues for identifying sarcopenia targets.
  • Individual omics technologies provide a limited view; integrative multi-omics analyses are essential for a holistic understanding.
  • Multi-omics data can reveal complex biological interactions underlying sarcopenia.

Conclusions:

  • Integrative multi-omics approaches are vital for a comprehensive understanding of sarcopenia etiology.
  • This review provides insights into sarcopenia pathogenesis and potential clinical applications.
  • Recommendations are offered for future research, prevention, and therapeutic interventions for sarcopenia.