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Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
Published on: July 23, 2012
Clinical analysis of relapsing polychondritis with airway involvement
1Department of Otorhinolaryngology Head and Neck Surgery, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi, China.
Objective:
To identify the clinical characteristics, treatment, and prognosis of relapsing polychondritis patients with airway involvement.
Methods:
Twenty-eight patients with relapsing polychondritis, hospitalised in the First Hospital of Shanxi Medical University between April 2011 and April 2021, were retrospectively analysed.
Results:
Fifty per cent of relapsing polychondritis patients with airway involvement had a lower risk of ear and ocular involvement. Relapsing polychondritis patients with airway involvement had a longer time-to-diagnosis (p < 0.001), a poorer outcome following glucocorticoid combined with immunosuppressant treatment (p = 0.004), and a higher recurrence rate than those without airway involvement (p = 0.004). The rates of positive findings on chest computed tomography and bronchoscopy in relapsing polychondritis patients with airway involvement were 88.9 per cent and 85.7 per cent, respectively. Laryngoscopy analysis showed that 66.7 per cent of relapsing polychondritis patients had varying degrees of mucosal lesions.
Conclusion:
For relapsing polychondritis patients with airway involvement, drug treatment should be combined with local airway management.
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