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Updated: Oct 4, 2025

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
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Interatrial Stent to Treat Stiff Left Atrium Syndrome

Danish Zaidi1, Derek Williams2, David Zhao3

  • 1Department of Internal Medicine, Yale-New Haven Hospital, New Haven, CT, United States of America.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|February 2, 2022
PubMed

Insights

Stiff left atrial syndrome (SLAS), a complication of catheter ablation for atrial fibrillation, can be treated with atrial septostomy. An interatrial stent was used to maintain the therapeutic benefit of septostomy in a patient with symptomatic SLAS.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Electrophysiology

Background:

  • Catheter ablation for atrial fibrillation (CAAF) can lead to stiff left atrial syndrome (SLAS) in up to 8% of patients.
  • SLAS diagnosis is challenging, often confused with heart failure with preserved ejection fraction (HFpEF) due to overlapping symptoms.
  • Current treatment options for SLAS can be limited.

Observation:

  • This case report details the first use of an interatrial stent to sustain the benefits of atrial septostomy in a patient with symptomatic SLAS.
  • The patient presented with symptoms consistent with SLAS following CAAF.
  • Interatrial shunt devices have shown promise for HFpEF but their use in SLAS was previously undescribed.

Findings:

  • Atrial septostomy provided significant symptomatic relief for the patient with SLAS.
  • The interatrial stent successfully maintained the patency and therapeutic effect of the atrial septostomy.
  • This intervention offers a novel approach to managing complex SLAS cases.

Implications:

  • SLAS should be considered in patients with dyspnea after CAAF, especially when other causes are ruled out.
  • Interatrial stenting may be a valuable technique to enhance the efficacy and durability of atrial septostomy for SLAS.
  • This approach could offer a new therapeutic avenue for patients with refractory SLAS.
Abstract

Keywords:
AblationAtrial fibrillationChronic heart failureHemodynamicsPulmonary hypertension

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