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Surface wave elastography using high speed full-field optical interferometry
Amandeep Singh1, Pawan Kumar1, Sriya Yeleswarapu2
1Medical Optics and Sensors Laboratory, Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana-502284, India.
Biomedical Physics & Engineering Express
|February 2, 2022
Summary
This study introduces a novel high-speed optical elastography method to measure tissue stiffness. This technique accurately quantifies biomechanical properties for potential non-invasive clinical diagnosis.
Area of Science:
- Biophysics
- Biomedical Engineering
- Optical Physics
Background:
- Mechanical stiffness assessment is crucial for understanding biological tissue biomechanics.
- Surface wave elastography (SWE) is an emerging technique for quantifying tissue elasticity.
- High-speed optical imaging offers potential for microscale elastography.
Purpose of the Study:
- To implement surface wave elastography using high-speed optical interferometry.
- To characterize the elastic properties of tissue phantoms and ex-vivo caprine liver tissue.
- To validate the optical system against mechanical compression testing.
Main Methods:
- Surface wave elastography with high-speed optical interferometry.
- Sinusoidal mechanical excitations (120 Hz to 1.2 kHz) applied to tissue surfaces.
- High-speed camera (4 kHz frame rate) for capturing surface waves at micrometer resolution.
- Phase-shifting algorithm for wavefront reconstruction and linear regression for velocity calculation.
Main Results:
- Successfully characterized elastic properties of tissue phantoms and liver tissue.
- Demonstrated correlation between optical system measurements and mechanical compression testing.
- Achieved micrometer resolution for surface wave imaging.
Conclusions:
- The multimodal platform combining optical interferometry and SWE shows promise for non-invasive/minimally invasive tissue characterization.
- Potential for future in-vivo and ex-vivo clinical applications in mechanical characterization.
- High-speed optical elastography provides accurate biomechanical property assessment.
