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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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A Test Bed to Examine Helmet Fit and Retention and Biomechanical Measures of Head and Neck Injury in Simulated Impact
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Octogenarian Motor Vehicle Collisions: Injury Patterns Matter.

Michael L Lemon1, Stephen D Helmer1, Kathryn Sobba1

  • 1Department of Surgery, University of Kansas School of Medicine-Wichita, Wichita, KS.

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|February 2, 2022
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Summary

Motor vehicle collisions (MVCs) pose a significant risk to octogenarians, with mortality linked to injury severity and in-hospital complications, not prior health conditions. This highlights the need for targeted interventions for older adults after MVCs.

Keywords:
comorbiditymortalityoctogenarianpolypharmacytraffic accidents

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Area of Science:

  • Trauma surgery
  • Geriatric medicine
  • Public health

Background:

  • Motor vehicle collisions (MVCs) are a leading cause of injury in octogenarians.
  • This demographic exhibits higher-than-expected mortality rates following trauma.
  • Factors influencing outcomes in elderly trauma patients require investigation.

Purpose of the Study:

  • To examine factors influencing mortality in octogenarians injured in MVCs.
  • To identify predictors of adverse outcomes in this vulnerable population.
  • To differentiate between pre-existing conditions and injury-related factors affecting mortality.

Main Methods:

  • Retrospective review of 239 patients aged 80+ involved in MVCs over 10 years.
  • Data collection included demographics, comorbidities, medications, injury details, and hospital interventions.
  • Analysis correlated patient factors and interventions with mortality outcomes.

Main Results:

  • Overall mortality rate was 18.8% among octogenarian MVC patients.
  • Increased mortality was associated with severe injury patterns, rural settings, blood transfusion, intubation, and ICU admission.
  • No significant correlation was found between mortality and pre-existing comorbidities or medications.

Conclusions:

  • Mortality in octogenarians post-MVC is primarily driven by injury severity and in-hospital complications.
  • Pre-existing comorbidities and medications did not significantly correlate with increased mortality.
  • Focusing on injury management and critical care interventions is crucial for improving outcomes.