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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

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The Paradox of Prosthetic Joint Infection and the Microbiome: Are Some Bacteria Actually Helpful?

Ayesha Abdeen1, Craig J Della Valle2, Daniel Kendoff3

  • 1Department of Orthopaedic Surgery, Boston Medical Center, Boston, MA, USA.

Arthroplasty Today
|February 2, 2022
PubMed

Insights

Periprosthetic joint infection (PJI) is a serious complication after joint replacement surgery. Investigating the role of the microbiome may reveal new ways to prevent and treat PJI.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Microbiology

Background:

  • Periprosthetic joint infection (PJI) is a severe complication following total joint arthroplasty.
  • PJI presents a substantial burden of illness and economic cost.
  • Current prevention strategies, including risk factor modification and prophylactic protocols, are not always effective.

Purpose of the Study:

  • To explore the potential role of the microbiome in the pathogenesis of PJI.
  • To investigate why PJI occurs even when risk factors are managed and protocols are followed.
  • To identify novel avenues for PJI prevention and treatment.

Main Methods:

  • This study reviews emerging evidence on the microbiome's role in musculoskeletal infections.
  • The focus is on understanding the impact of commensal microorganisms on PJI development.
  • Further investigation into the microbiome's influence on PJI is warranted.

Main Results:

  • The microbiome, comprising diverse commensal microorganisms, is increasingly implicated in musculoskeletal infections.
  • Emerging evidence suggests a link between the host microbiome and PJI pathogenesis.
  • The precise mechanisms by which the microbiome influences PJI require further elucidation.

Conclusions:

  • The microbiome may play a significant role in the development of PJI.
  • Understanding the microbiome's impact could revolutionize PJI prevention and treatment strategies.
  • Further research is crucial to harness microbiome insights for improved patient outcomes in joint arthroplasty.
Keywords:
ArthroplastyDysbiosisMicrobiomePeriprosthetic joint infection

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