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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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Digital DNA lifecycle security and privacy: an overview.

Muhalb M Alsaffar1, Mohammad Hasan, Gavin P McStay2

  • 1Department of Computing, AI and Robotics, School of Digital, Technologies and Arts, Staffordshire University, College Road, ST4 2DE, Staffordshire, United Kingdom.

Briefings in Bioinformatics
|February 2, 2022
PubMed
Summary
This summary is machine-generated.

Advancements in DNA sequencing offer personalized medicine but raise privacy concerns. This article explores the digital DNA life cycle, identifying threats and mitigation strategies for genomic data security.

Keywords:
DNA attackDNA privacyDNA securitydigital DNA attacksdigital DNA life cycledirect-to-consumer (DTC) securitygenomic attacksgenomic privacygenomic privacy-preserving techniquesgenomic securityre-creational genomic security

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Area of Science:

  • Genomics
  • Biomedical Research
  • Bioinformatics

Background:

  • Rapid advancements in DNA sequencing technologies have driven progress in personalized medicine and disease treatment discovery.
  • Decreased sequencing costs have fueled the growth of direct-to-consumer (DTC) genomic services.
  • Significant privacy and security concerns accompany the collection, analysis, and sharing of DNA and genomic data.

Purpose of the Study:

  • To define the 'digital DNA life cycle'.
  • To provide an overview of privacy and security threats throughout the digital DNA life cycle.
  • To examine privacy and security issues specific to DTC genomic sequencing.

Main Methods:

  • Review of DNA sequencing hardware, software, and data pipelines.
  • Analysis of common privacy attacks on digital DNA data.
  • Examination of countermeasures for data storage, querying, and sharing.

Main Results:

  • Identification of unique privacy and security vulnerabilities across the digital DNA life cycle.
  • Discussion of how DNA data breaches can impact individuals and their relatives due to its hereditary nature.
  • Assessment of specific risks associated with DTC genomic sequencing.

Conclusions:

  • The digital DNA life cycle necessitates robust privacy and security measures.
  • Effective mitigation techniques are crucial for protecting sensitive genomic information.
  • Addressing privacy concerns is vital for the responsible advancement of genomic technologies and DTC services.