[Prostacyclin control of thrombocyte-vascular hemostasis in irradiation]

Disorders in prostacyclin control of the functional state of thrombocyte-vascular wall system are associated rather with decreased PGI2 stability in the blood flow, its accelerated decomposition and as a result with its shorter and weaker effect on thrombocyte-vascular hemostasis, than with the decline in PGI2 synthesis. It is suggested that rapid PGI2 decomposition in irradiation may significantly limit its therapeutic effect, requiring adequate correction of PGI2 dosage and mode of administration.