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Updated: Oct 4, 2025

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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BSAC Vanguard Series: Inequality and antibiotic resistance

Marc Mendelson1

  • 1Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, G16.68 New Main Building, 7925 Cape Town, South Africa.

The Journal of Antimicrobial Chemotherapy
|February 2, 2022
PubMed

Insights

Addressing antibiotic resistance (ABR) globally requires tackling infectious diseases in low- and middle-income countries (LMICs). Increased funding for interventions like sanitation, clean water, and vaccination is crucial for antibiotic conservation worldwide.

Area of Science:

  • Global Health
  • Infectious Disease Epidemiology
  • Antimicrobial Resistance

Background:

  • The COVID-19 pandemic exposed global health inequities, mirroring challenges in combating antibiotic resistance (ABR).
  • Antibiotic resistance is a projected to cause greater devastation than the COVID-19 pandemic if not addressed.
  • Current efforts largely focus on new antibiotic development and surveillance, neglecting crucial interventions.

Purpose of the Study:

  • To highlight the critical need for addressing infectious diseases in low- and middle-income countries (LMICs) to impact global ABR.
  • To advocate for increased investment in non-pharmaceutical interventions for antibiotic conservation.
  • To emphasize the necessity of large-scale public health interventions and dedicated funding mechanisms for LMICs.

Main Methods:

  • This study is a review and analysis of current global health strategies and funding for infectious diseases and ABR.
  • It synthesizes evidence on the impact of interventions such as sanitation, clean water, vaccination, and agricultural practices on antimicrobial use.
  • The analysis emphasizes the need for a shift in resource allocation towards public health infrastructure in LMICs.

Main Results:

  • Despite significant investment in new antibiotics, progress in antibiotic conservation remains limited.
  • Insufficient resources are allocated to essential interventions like infection prevention, sanitation, clean water, and vaccination.
  • Failure to address infectious disease burdens in LMICs hinders global efforts against ABR.

Conclusions:

  • Effective global antibiotic resistance containment necessitates a focus on strengthening public health infrastructure and interventions in LMICs.
  • Substantial investment in sanitation, clean water, vaccination, and changes in agricultural practices is vital for antibiotic conservation.
  • High-level action and dedicated funding mechanisms are required to support LMICs in implementing these critical changes.

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