Related Experiment Video
Updated: Oct 4, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Slowdown in Mortality Improvement in the Past Decade: A US/UK Comparison
Michael J Murphy1,2, Emily M D Grundy3,4
1Department of Social Policy, London School of Economics and Political Science, London, UK.
Objectives:
To investigate the slowdown in mortality improvement in the United States, United Kingdom, and comparator countries observed in the first decade of the twenty-first century and critically evaluate proposed explanations.
Methods:
Change-point analysis to identify the year of change in comparison of national mortality trends and linear spline models in the investigation of subnational differences using data from the Human Mortality Database, Global Burden of Disease cause-specific data, and, for the United Kingdom, national statistics data. Consideration of the impact of using different methods to estimate overall mortality is also concluded together with a review of methodological assumptions made in previous studies.
Results:
The results confirm the slowdown in mortality improvement observed in the early twenty-first century but indicate that proposed explanations for this are inadequate on a range of counts.
Discussion:
Mortality improvement slowed down in the early twenty-first century but the explanations advanced, such as opioid use in the United States or influenza epidemics and austerity programs in the United Kingdom, seem unlikely to account for this. Further research considering longer-term life course and cohort influences is needed.
Related Concept Videos
Actuarial Approach
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Comparing the Survival Analysis of Two or More Groups
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Kaplan-Meier Approach
Regression Toward the Mean
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

